Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice

Main Article Content

Jui-Cheng Chen
Cheng-Chih Tsai
Chang-Chi Hsieh
Alice Lan
Chun-Chih Huang
Sew-Fen Leu

Keywords

Lactobacillus plantarum, Pediococcus acidilactici, Anti-allergy, Airway hyperreactivity

Abstract

Background: Probiotics could be beneficial to health and some of them have shown to modulate immune responses.


Aim: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model.


Methods: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks. A barometric whole-body plethysmography was used to assess enhanced pause (Penh) of airway hyperactivity (AHR). Immunoglobulins (Ig) such as IgE, IgG1, IgG2a and cytokines such as IL-12, IFN-γ, IL-4, IL-5, TNF-α and IL-13 in bronchoalveolar lavage fluid were assayed using ELISA kits.

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