Tolerance induction to LTP in patients with anaphylaxis: Serological response markers
Main Article Content
Keywords
Oral Immunotherapy, LTP Allergy, Pru p 3, Anaphylaxis, Serological Biomarkers, Specific IgE, Specific IgG4, Induced Tolerance
Abstract
Introduction: Allergy to lipid transfer proteins (LTP) is one of the leading causes of anaphylaxis in the Mediterranean region. Oral immunotherapy, sublingual immunotherapy (SLIT), with peach extract has emerged as a strategy to induce tolerance.
Objective: This study aimed to evaluate the efficacy of SLIT with peach extract and the usefulness of serological biomarkers as predictors of clinical response in patients with LTP-related anaphylaxis.
Methods: Observational study involving 80 patients diagnosed with LTP syndrome. Total IgE levels, specific IgE, and IgG4 specific to Pru p 3 were measured before and after 1 year of treatment. Patients were classified based on tolerance at the end of therapy.
Results: Sixty-one patients (76.3%) tolerated the final oral challenge. Baseline levels of total IgE, specific IgE, and IgG4 specific to Pru p 3 were significantly higher in the tolerance group. IgG4 levels increased significantly in both groups after treatment. Specific IgE levels increased only in the nontolerance group.
Conclusions: SLIT with peach extract may induce tolerance in the majority of patients with LTP allergy. Elevated baseline levels of total IgE, specific IgE, and IgG4 specific to Pru p 3 could serve as markers of clinical response.
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