Evaluation of bronchial mucoza and minor salivary gland byopsy in patients with sarcoidosis by flow volume maneuver
Main Article Content
Keywords
minor salivary gland biopsy, mucosal biopsy, sarcoidosis, endobronchial sarcoidosis
Abstract
Introductıon: The aim of our study was to determine predicting endobronchial sarcoidosis by considering minor salivary gland involvement, pulmonary function test, and bronchoscopic images.
Material and Methods: A total of 219 cases of sarcoidosis were retrospectively investigated. All cases were analyzed for age, gender, cigarette consumption, proven sarcoidosis skin biopsy, erythema nodosum, eye examination, minor salivary gland biopsy (MSGB), pulmonary functional evaluation, DLCO, six-minute walk test, angiotensin-converting enzyme level, erythrocyte sedimentation rate, radiologic stages, biopsies for diagnosis, bronchoscopic mucosal appearance, and biopsy results.
Results: A total of of 219 cases (M:41, F:178); mean age was 45.9 ± 11.8 (20–75). Erythema nodosum in 67 (30.6%) cases. Radiological stages: Grade 0: 15 (6.9%), Grade 1: 104 (47.6%), Grade 2: 67 (30.5%), Grade 3: 22 (10%), and Grade 4: 11(5%). Of the total cases, 215 (98.1%) were diagnosed with at least one invasive procedure; 155 (70.7%) were from two or more sites. Sarcoidosis involvement of endobronchial mucosa with bronchoscopic imaging was found in 25 (16%); mucosal biopsy was found in 64 (41%); microscopic findings suggestive of sarcoidosis were observed in 30 (46.9%). Forty (18.2%) cases had obstructive pattern in the end airway. Thirty (46.9%) cases were diagnosed with endobronchial sarcoidosis by mucosal biopsy, and terminal airway stenosis was seen in seven (23.3%) cases. In patients diagnosed with endobronchial sarcoidosis by mucosal biopsy, terminal airway stenosis was observed in 23.3%, compared with 18.2% in the overall cohort. Bronchoscopic mucosal biopsy was positive in 25.8% (n= 8) of the cases with positive MSGB. Eight cases had MSGB, and findings were suggestive of sarcoidosis in the bronchoscopic appearance. The number of cases with positive mucosal biopsy results was 62.5% (n=5); a weak, significant correlation was found between positivity of MSGB and bronchoscopic transbronchial lymph node aspiration. There was also a weak, significant correlation between MSGB and bronchoscopic mucosal biopsy positivity. A statistically weak correlation was found between MSGB and bronchoscopic appearance and endobronchial sarcoidosis involvement.
Conclusion: MSGB positivity can be used to predict bronchoscopic direct examination and mucosal biopsy positivity.
References
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