Efficacy of air purifier therapy for patients with allergic asthma

Main Article Content

Luo Jia-ying
Ou Li-li
Ma Jing
Lin Xin-yuan
Fan Li-min
Liu Hai-cheng
Sun Bao-qing


air purifier, allergic asthma, fractional exhaled nitric oxide, house dust mite, particulate matter


Objectives: This study aimed to evaluate the efficacy of air purifier therapy for patients with allergic asthma.

Methods: Thirty-eight subjects were categorized under two groups namely treatment group and control group. All subjects were under 18 years of age and they had been clinically diagnosed with allergic asthma. The treatment group used high efficiency particulate air (HEPA) purifiers for six consecutive months, and the control group did not use the air filters. Particulate matter (PM) data and dust samples (from bedding and a static point) were collected from the subjects’ bedrooms before they started using the air purifiers and each month thereafter. Simultaneously, the subjects were asked to complete a questionnaire for the Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT). Fractional exhaled nitric oxide (FENO) tests were performed at the start and end of the study. The concentrations of Der p1 and Der f1 were measured in the dust samples.

Results: (1) After utilizing the air purifier, the concentrations of house dust mite (HDM) allergens (Der p1+ Der f1) in the dust samples decreased. In addition, the PMindoor/outdoor values significantly decreased. (2) The ACT and C-ACT scores in the treatment group maintained a steady significant upward trend. (3) At the end of the study, the FENO levels in both groups were lower, although the differences were not significant.

Conclusions: It is witnessed that HEPA air purifiers can decrease indoor HDM allergen and PM levels and improve the quality of life for allergic asthma patients.

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1. The Global Asthma Network. The global asthma report 2018. Auckland, New Zealand: Global Asthma Network, 2018.

2. Romanet-Manent S, Charpin D, Magnan A, Lanteaume A, Vervloet D. Allergic vs nonallergic asthma: what makes the difference? Allergy. 2002;57:607–613. 10.1034/j.1398-9995.2002.23504.x

3. World Health Organization Asthma. [accessed on 16 October 2016]. https://www.who.int/news-room/fact-sheets/detail/asthma

4. Falcon-Rodriguez CI, Osornio-Vargas AR, Sada-Ovalle I, Segura-Medina P. Aeroparticles, composition, and lung diseases. Front Immunol. 2016;7:3. 10.3389/fimmu.2016.00003

5. Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009;64:1083–1092. 10.1111/j.1398-9995.2009.01967.x

6. Li J, Wang H, Chen Y, Zheng J, Wong GW, Zhong N. House dust mite sensitization is the main risk factor for the increase in prevalence of wheeze in 13-to 14-year-old schoolchildren in Guangzhou city, China. Clin Exp Allergy. 2013;43:1171–1179. 10.1111/cea.12157

7. Zhang C, Gjesing B, Lai X, Li J, Spangfort MD, Zhong N. Indoor allergen levels in Guangzhou city, southern China. Allergy. 2011;66:186–191. 10.1111/j.1398-9995.2010.02465.x

8. Kajbafzadeh M, Brauer M, Karlen B, Carlsten C, van Eeden S, Allen RW. The impacts of traffic-related and wood smoke particulate matter on measures of cardiovascular health: a HEPA filter intervention study. Occup Environ Med. 2015;72:394–400. 10.1136/oemed-2014-102696

9. Global Initiative for Asthma. Global strategy for asthma management and prevention, 2018. Available from: www.qinasthma.org.

10. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65. 10.1016/j.jaci.2003.09.008

11. Liu AH, Zeiger R, Sorkness C, Mahr T, Ostrom N, Burgess S, et al. Development and cross-sectional validation of the childhood asthma control test. J Allergy Clin Immunol. 2007;119:817–825. 10.1016/j.jaci.2006.12.662

12. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–615. 10.1164/rccm.9120-11ST

13. Licari A, Brambilla I, Marseglia A, De Filippo M, Paganelli V, Marseglia GL. Difficult vs.severe asthma: definition and limits of asthma control in the pediatric population. From Pediatr. 2018;6:170. 10.3389/fped.2018.00170

14. Park S, Lee EH, Kho Y. The association of asthma, total IgE, and blood lead and cadmium levels. J Allergy Clin Immunol. 2016;138:1701–1703.e6. 10.1016/j.jaci.2016.04.030

15. Sierra-Heredia C, North M, Brook J, Daly C, Ellis AK, Henderson D, et al. Aeroallergens in Canada: distribution, public health impacts, and opportunities for prevention. Int J Environ Res Public Health. 2018;15:1577. 10.3390/ijerph15081577

16. Jia-Ying L, Zhao C, Jia-Jun G, Zi-Jun G, Xiao L, Bao-Qing S. Efficacy of air purifier therapy in allergic rhiniti. Asian Pac J Allergy Immunol. 2018;36:217–221. 10.12932/AP-010717-0109

17. Lin PY, Chu CH, Chang FY, Huang YW, Tsai HJ, Yao TC. Trends and prescription patterns of traditional Chinese medicine use among subjects with allergic diseases: a nationwide population-based study. World Allergy Organ J. 2019;12:100001. 10.1016/j.waojou.2018.11.001

18. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005;116:517–524. 10.1016/j.jaci.2005.05.029

19. Chang TT, Huang CC, Hsu CH. Clinical evaluation of the Chinese herbal medicine formula STA-1 in the treatment of allergic asthma. Phytother Res PTR. 2006;20:342–347. 10.1002/ptr.1843

20. Wang Y, Liu K, Hu K, Yang J, Li Z, Nie M, et al. Impact of obstructive sleep apnea on severe asthma exacerbations. Sleep Med. 2016;26:1–5. 10.1016/j.sleep.2016.06.013

21. Xiang L, Fu Y, Wang J, Wang Q. [The correlation between the seasonal variation of house dust mite allergens exposure level in household and the level of asthma control in asthmatic children]. Zhonghua Er Ke Za Zhi. 2014;52:177–183.

22. Paulin LM, Diette GB, Scott M, McCormack MC, Matsui EC, Curtin-Brosnan J, et al. Home interventions are effective at decreasing indoor nitrogen dioxide concentrations. Indoor Air. 2014;24:416–424. 10.1111/ina.12085