Administration of adrenaline by trainee teachers in a simulated anaphylactic reaction: intramuscular versus intranasal use

Main Article Content

Aida Carballo-Fazanes https://orcid.org/0000-0001-6615-9821
Pablo Chico-Vigo
Antonio Rodríguez-Núñez https://orcid.org/0000-0003-3414-2771
Graciela Gómez-Silva https://orcid.org/0000-0003-1806-5761
Carlos Garcia-Magan https://orcid.org/0000-0003-4644-1242
Cristian Abelairas-Gómez https://orcid.org/0000-0002-1056-7778

Keywords

adrenaline autoinjector, anaphylaxis, intranasal atomizer, school emergencies, teacher training

Abstract

Introduction: Anaphylactic reactions represent a serious risk for children within the school environment. It is essential that teachers are prepared to respond quickly and effectively. The objective of this study was to evaluate the ability of trainee teachers to administer adrenaline, both intramuscularly and intranasally, in a simulated anaphylactic shock scenario.


Material and methods: This quasi-experimental pilot study included 23 undergraduate students in Primary Education who received training in managing severe allergic reactions. They were evaluated twice in a simulated anaphylaxis scenario. In the first test, participants chose the adrenaline device (intramuscular or intranasal). In the second, they repeated the scenario using the alternative device. Variables related to the execution of each step and the time required were recorded.


Results: More than 80% of participants correctly completed all steps with the intranasal device. However, greater difficulties appeared with the intramuscular autoinjector, particularly maintaining it in position for at least 5 seconds and massaging the area afterward, which only 20% completed. The correct compliance rate was significantly higher with the intranasal device (100% vs. 71.43%, p = 0.012), and the administration time was shorter (p = 0.022). Initially, almost 70% chose the intramuscular autoinjector, but after testing both devices, 60.9% preferred the intranasal route.


Conclusions: A brief theoretical–practical training session is effective in training future teachers to respond appropriately to anaphylaxis in schools. Participants preferred the intranasal route for its simplicity and lower invasiveness.

Abstract 140 | PDF Downloads 132 HTML Downloads 0 XML Downloads 4

References

1 Gómez-Silva G, Carollo-Motellón M, Abelairas-Gómez C, Sánchez-Santos L, García-Doval FM, Rodríguez-Núñez A. Schoolchildren with chronic diseases; what are teachers worried about?. An Pediatr. 2020;93(6):374-9. 10.1016/j.anpedi.2020.02.004

2 Cantariño SF, Novío-Mallón S. Level of competence of primary and secondary school teachers in the management of anaphylaxis. Ann Allergy Asthma Immunol. 2019; 122:117-8. 10.1016/j.anai.2018.09.465

3 Pouessel G, Dumond P, Liabeuf V, Kase-Tanno L, Deschildre A, Beaumont P et al. Gaps in the management of food-induced anaphylaxis reactions at school. Pediatr Allergy Immunol. 2019;30(7):767-70. 10.1111/pai.13091

4 European Medicines Agency. Summary of opinion (initial authorisation): Eurneffy. Epinephrine, https://www.ema.europa.eu/en/medicines/human/EPAR/eurneffy; 2024 [accessed 2025/MARCH/8]

5 Lapidot T, Tal Y, Megiddo D, Krayz GT, Abrutzky C, Blotnick S, et al. First-in-class intranasal epinephrine spray for anaphylaxis: Dose finding clinical study. J Allergy Clin Immunol Glob. 2025;4(3):100487. 10.1016/j.jacig.2025.100487

6 Casale TB, Ellis AK, Nowak-Wegrzyn A, Kaliner M, Lowenthal R, Tanimoto S. Pharmacokinetics/pharmacodynamics of epinephrine after single and repeat administration of neffy, EpiPen, and manual intramuscular injection. J Allergy Clin Immunol. 2023 Dec;152(6):1587–96. 10.1016/j.jaci.2023.08.007

7 Van de Voorde P, Turner NM, Djakow J, De Lucas N, Martínez-Mejías A, Biarent D et al. European Resuscitation Council Guidelines 2021: Paediatric Life Support. ERC. 2021;161:327-87. 10.1016/j.resuscitation.2021.02.015

8 Rodríguez-Ferrán L, Gómez-Tornero N, Cortés-Álvarez N, Thorndike-Piedra F. Anaphylaxis at school. Are we prepared? Could we improve? Allergol Immunopathol. 2020;48(4):384-9. 10.1016/j.aller.2019.10.006

9 Abelairas-Gómez C, Carballo-Fazanes A, Martínez-Isasi S, López-García S, Rico-Díaz J, Rodríguez-Núñez A. Knowledge and attitudes on first aid and basic life support of Primary and Preschool teachers and parents. An Pediatr. 2020;92(5): 268-76. 10.1016/j.anpedi.2019.10.01031

10 Devetak I, Posega-Devetak S, Vesel T. Future teachers’ attitudes and knowledge regarding the management of the potential students’ life-threatening allergic reac-tions in slovenian schools. Zdr Varst. 2018;57(3):124-32. 10.2478/sjph-2018-0016

11 Settles JA, Gerety GF, Spaepen E, Gideon-Suico J, Child CJ. Nasal glucagon delivery is more successful than injectable delivery: a simulated severe hypoglycemia rescue. Endocr Pract. 2020;26(4):407-15. 10.4158/EP-2019-0502

12 Santos MJL, Merrill KA, Gerdts JD, Ben-Shoshan B, Protudjer JLP. Food Allergy Education and Management in Schools: A Scoping Review on Current Practices and Gaps. Nutrients. 2022;14:732. 10.3390/nu14040732

13 Chmiel-Perzyńska I, Derkacz M, Grywalska E, Kowal A, Schabowski J, Nowakowski A. The knowledge about hypoglycemia among primary school teachers in the Lubelskie Province in Poland. Diabetologia Doswiadczalna i Kliniczna. 2008;8(4):157-8.